While the idea of a protective mechanism of coffee on chronic disease is not a big surprise given the low calorie and high polyphenol content, the risk reductions for all cause mortality were a little higher than I would have expected and demonstrated somewhat of a parabolic curve, with higher intakes have less protection. In men, greater than 6 cups / day led to a large 20% reduction in death. In women, 4-5 cups / day led to an 26% reduction, while greater than 6 cups / day led to a reduced (but still great) 17% reduction. These are pretty large numbers for something that had been viewed as detrimental for many years. So much for dogma.