Celecoxib, rofecoxib, and acute temporary visual impairment
Another wonderful example of how little we know of human physiology. Basically, we don’t fully begin to grasp the complexity of an enzyme until we begin shutting it down on a grand scale; i.e. FDA approval. We thought we knew what cyclo-oxygenase 2 did until we released the new wonder arthritis drugs Celebrex and Vioxx. Now we are seeing that COX-2 is essential for heart health, bone formation and now maybe some visual impacts as well.
bmj.com Coulter et al. 327 (7425): 1214.