Protein glycosylation in vivo induces autoimmune disease
The glycosylation of proteins occurs when glucose reacts with proteins to change their structure and function. Some consider this the basis of aging. While this research study uses genetic modification to induce autoimmune disease, there are some implications that glycosylation from insulin resistance may be a triggering factor in some autoimmune diseases.
PNAS — Abstracts: Chui et al. 98 (3): 1142