Insulin Sensitivity after Metformin Suspension in Normal Weight Women with PCOS.
I have long asserted that we are handling infertility in a very poor manner. In most cases, infertility is related to poor lifestyle, and not addressing these lifestyle factors opens up an entire Pandora’s Box of potential problems, both with pregnancy, pregnancy outcomes and the long term health of the child.So, the ONLY real answer is lifestyle changes. But alas, many women with PCOS (the main cause of infertility here in the US) are just given Metformin, a drug that increases insulin sensitivity in the liver.
This study evaluated what happened when those patients were taken OFF of this drug. Interestingly, the women with PCOS were WORSE OFF after the treatment then before!! It just reinforces the idea that drugs are not the answer for this condition, and any other approach that doesn’t address lifestyle is likely to make the condition worse. Also, consider that Metformin only works in the liver. A few articles back, we saw that insulin resistance in the muscle is a major factor in the development of MetS, and yet Metformin does nothing to address this aspect.