Activation of the mucosal immune system in irritable bowel syndrome
It has been difficult to find structural abnormalities in IBS and it is nice to see some research along these lines. IBS is primarily a functional disorder and I’m sure that the localized inflammation found in this study is a result of the altered function. Imbalance in pathogenic flora, improper digestion leading to putrefactive by products and yeast overgrowth have all shown to play a factor in IBS. Each of these by themselves could lead to a localized inflammatory response.
Gastroenterology Online