Trial of doxycycline for chronic seronegative arthritis
While the concept that certain patients arthritis may be initiated by an infective agent is wonderful, the findings in this study that antibiotics do not change the outcome is not at all surprising. Much evidence points to the scenario that an infectious agent (more often than not from the GI tract) upregulates the entire immune system. This upregulation ultimately results in the body attacking its own tissues. The key for these patients is to down regulate the immune system. This can be done with elimination diets, avoidance of refined carbs, essential fatty acids, exercise and natural anti-inflammatories.
Ann Rheum Dis — Abstracts: Smieja et al. 60 (12): 1088