Comet assay w/ mouse organs: results with 39 currently used food additives
Sucralose in this study showed DNA damage. Now, in total, many other studies have not shown this finding with sucralose.
I do bring this study up to demonstrate that we do not yet know enough about this compound for me to recommend it to patients. For now I recommend avoiding it (and most likely this recommendation will stay…) just as with aspartame. The concern is that this sweetener is being used in more and more foods.
Recently heard a commercial for “no sugar added” Ovaltine or something like that. Well–the “no sugar added” was a codeword for sucralose (Splenda). Remember that anytime we try to come up with a compound to avoid the lifestyle changes that we know we need to make (olestra, aspartame, “carb blockers”…) the results are usually less than perfect.
Entrez-PubMed.