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Parkinson's

Neurodegeneration: Dementia Support Starts Here

August 31, 2012 by James Bogash

Alzheimer’s and Parkinsons are fearsome. The neurodegeneration robs you of your mind and body. Prevention is possible, but dementia support has to start NOW.

I know that I’ve covered the mitochondria before since it is, after all, everyone’s favorite organelle.  But it never hurts to review (besides, if you ever get on Jeopardy you can say, “Alex, I’ll take cellular organelles for $500, please” with confidence).

Think way back to your high school biology class and the anatomy of a cell. To the mitochondria. The little “powerhouse of the cell.” That little organelle within the cell that helps to generate energy for a cell. And the “energy currency” for every cell is adenosine triphosphate, or ATP. There are some billion or so reactions that occur in our body EVERY SECOND, and each one of these requires a molecule of ATP to get the job done.

Some tissues, like fat, use very little energy.

Others, like the heart, our muscles and our brain, use much more.

At rest, the nervous system, which includes our brain, is the greatest utilizer of ATP in the body. Once we start moving, the muscles take over and have the greatest need.

Poor lifestyle choices that lead to exposure to toxic chemicals, stress and processed foods begin to damage these precious little ATP-producing buggers.  Luckily, a lifestyle devoid of stress with minimal toxic exposure and lots of fruits, veggies and spices can protect our mitochondria.

However, if the brain cells lose too many of their own mitochondria through this damaging process, ultimately the remaining mitochondria can no longer keep up with the energy needs of the cell and the cell begins a process called apoptosis, or cell suicide.

If you can envision the solid Scottish accent of Scotty from Star Trek calling up to the bridge saying, “Captain, we can hold ‘er together anymore,” than you get an idea of what begins to happen (except Captain Kirk always seems to figure out the problem and save the USS Enterprise—not so much for our brains at this point…).

Left unchecked, this loss of neurons over the course of years can lead to other neurological conditions like Alzheimer’s or Parkinson’s.

If you would like to protect your brain and have it last at least as long as your body, then you need to begin NOW to protect it.  Ways to protect your brain from dementia and neurodegeneration have been covered in previous posts and can be read here.

This particular review looks at this process of damage to our mitochondria and the subsequent neurodegeneration that occurs.  I thought I’d throw it in just in case you thought that I really had no idea what I am talking about (especially since your neurologist has mentioned that we don’t know what causes the brain to break down).

If you have a family history of a neurodegenerative disorder, what changes have you made NOW to protect your brain?

Filed Under: Alzheimer's, Parkinson's Tagged With: Alzheimer's, mitochondria, neurodegeneration, Parkinson's, protect your brain

VITAMIN B12 AND B6 RISK FOR PARKINSON DISEASE – (12-04-06)

July 30, 2012 by James Bogash

Dietary folate, vitamin B12, and vitamin B6 and the risk of Parkinson disease

Some interesting findings in this study. First of all, they looked at dietary intake, NOT supplements, and found that higher levels of B6 were very protective for Parkinson’s (decreased risk over 50%), but ONLY in smokers. Don’t ask me yet what the mechanism of this protection is, but I’m sure we’ll have an answer in another 10 yrs or so..

Read entire article here

Filed Under: Parkinson's, Vitamin B12 Tagged With: B6, Dietary folate, Parkinson, Vitamin B12

HEALTHY FATS PROTECT BRAIN CELLS FROM DEATH – (09-06-05)

July 30, 2012 by James Bogash

Docosahexaenoic acid: A positive modulator of Akt signaling in neuronal survival

While this may get a little too deep into biochemistry for most of us, the bottom line is that certain types of healthy fats are protective to our brain.  This is yet another reason to believe that many of our neurodegenerative diseases such as Alzheimers and Parkinson’s are indeed diseases of lifestyle.  Less intake of healthy fats over a lifetime leaves brain cells more susceptible to damage and cell death.

Read entire article here

Filed Under: Alzheimer's, Parkinson's Tagged With: Alzheimer's, Docosahexaenoic acid, neurodegenerative diseases, Parkinson's

DIETARY FATTY ACIDS RISKS IN PARKINSON DISEASE – (07-18-05)

July 22, 2012 by James Bogash

Dietary fatty acids and the risk of Parkinson disease

While the finding that healthier fats lower the risk of Parkinson’s should be no surprise (most evidence is suggesting an inflammatory/mitochondrial dysfunction etiology for PD and Alzheimer’s and healthy fats will have an anti-inflammatory effect), the level of protection was a little surprising.

When looking at a hazard ratio, higher than 1.00 means an increased risk (a hazard ratio of 2.0 would mean a doubling of risk) and lower than 1.00 means a protective effect (.50 would mean half the risk).  The hazard ratio found was 0.68 for monounsaturated fat and 0.66 for polyunsaturated fats.

Read entire article here

Filed Under: Parkinson's Tagged With: Alzheimer's, Etiology, Mitochondrial dysfunction, Parkinson, PD

WHAT IS A GOOD SOLID BIOMARKER FOR PARKINSON DISEASE? – (03-28-05)

May 9, 2012 by James Bogash

Urinary 8-hydroxydeoxyguanosine levels as a biomarker for progression of Parkinson disease

Following up on the previous article, the base problem with using a mitochondrial dysfunction/oxidative stress model is that we have not yet identified a good, solid, commercially available marker.

This article helps in that regards in suggesting that 8-OHDG, a marker of oxidative damage to DNA, may be a viable option.  Interestingly and, not surprisingly, the treatment of choice for Parkinson’s, l-dopa, did not affect 8-OHDG levels.

Read entire article here

Filed Under: Parkinson's Tagged With: 8-OHDG, l-dopa, Mitochondrial dysfunction, oxidative stress, Parkinson's

WHAT ARE THE FUTURE RISKS OF USING CELL PHONES? – (04-25-05)

May 6, 2012 by James Bogash

Antidepressant-like effects of cranial stimulation w/in low-energy magnetic field in rats

This study raises some very interesting questions and concerns.  First, there is the therapy aspect–might some form of electrical/magnetic stimulation positively affect our mood?  Next, what about deleterious effects of cell phones, microwaves, headphones, diagnostic testing, etc…?

I personally think that, when all the chips fall, in 30 yrs or so we will find that cell phone use has increased the risk/rate of some conditions like ADD/ADHD, brain tumors, seizures, Alzheimer/Parkinson’s.

Read entire article here

Filed Under: Alzheimer's, Parkinson's, Seizures / Epilepsy Tagged With: ADD/ADHD, Alzheimer/Parkinson’s, brain tumors, cell phones, seizures / epilepsy

DAIRY INTAKE LEADS TO FUTURE RISK OF PARKINSON’S DISEASE – (04-25-05)

May 5, 2012 by James Bogash

Consumption of milk and calcium in midlife and the future risk of Parkinson

I’ve said it before, and I will say it again (and again, and again…) that I think the idea that cow’s milk “does a body good” is one of the most successful marketing campaigns based on little to no evidence ever exposed to the American public.  Good luck finding any articles not sponsored by the dairy industry that show a strong beneficial effect on dairy products for any condition.

Conversely, dairy intake has been linked to food allergy, ear infections, osteoporosis (or at least no protection from), Type 1 diabetes and now add Parkinson’s to the list.  Ironically, although this showed a 2.3 fold increase (quite a large increase) and it was in a major neurology journal, not a PEEP from the media.  Compare this to a 3-lb decrease in body weight over 6 months with dairy intake (and no-one just body fat–just weight) and you would think the Holy Grail for America’s weight problem was found.

Read entire article here

Filed Under: Parkinson's, Type 1 Diabetes Tagged With: dairy intake, ear infections, food allergy, neurology, osteoporosis, Parkinson, type 1 diabetes

HOW DOES REPRODUCTIVE-AGE HORMONE AFFECT THE BRAIN? – (07-23-07)

April 8, 2012 by James Bogash

The Neurosteroid Allopregnanolone is Reduced in Prefrontal Cortex in Alzheimer’s Disease

Allopregnanolone is considered one of the most potent GABA agonist on the planet, natural or synthetic. This means it has a potent ability to calm the brain cells down. Allopregnanolone is derived from progesterone. So how would what is thought of as a reproductive-age hormone affect the brain later in life? Actually the potential for interactions are great.

First, we know that the damage with Alzheimer’s and Parkinson’s start decades before symptoms, putting the time frames for beginning damage well into the reproductive years.In addition, Alzheimer’s is very strongly associated with insulin resistance, and IR is well known to inhibit ovulation and lower levels of progesterone. The bottom line, however, is the same as always–prevention of these age related chronic diseases begins decades earlier, and the approach to lowering risk is multifactorial.

Read entire article here

Filed Under: Alzheimer's, Ovulation, Parkinson's Tagged With: allopregnanolone, Alzheimer's, insulin resistance, ovulation, Parkinson's, progesterone

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