Archive for Crohn’s disease
Cannabidiol is anti-arthritic in murine collagen-induced arthritis
This article talks about the non-psychoactive component of cannibas being used orally as a treatment for arthritis. It was shown to lower TNF levels…the same messenger that the new expensive drugs for Crohn’s disease and rheumatoid arthritis lower.
PNAS — Abstracts: Malfait et al. 97 (17): 9561
Butyrate inhibits inflammation: implications for Crohn’s disease
More and more articles are being published support the role of butyrate in reducing severity and/or flare ups of gastrointestinal disorders. Remember that butyrate is produced when GOOD bacteria digest the fiber that we consume.
Gut — Abstracts: Segain et al. 47 (3): 397
Fatty acids reduce movement of protein across intestinal epithelium
It is common knowledge that fish oil can help with Crohn’s disease. This article suggests a mechanism for this benefit. Certain good fats can stabilize the gastrointestinal tract’s ability to keep bad stuff out of the body.
Journal of Gastroenterology and Hepatology 15 (6), 626-631 Both w-3 and w-6 polyunsaturated fatty acids reduce transcellular, non-receptor-mediated permeation of proteins across differentiated Caco2 cell monolayers, without altering paracellular permeability. Alteration of intestinal barrier function should be considered as a possible mechanism of action of dietary polyunsaturated fatty acids.
Mercury poisoning associated with a Mexican beauty cream** There are many examples of certain “health products” actually being high in certain heavy metals which damage our bodies. Shark cartilage can be an excellent example.
wjm — Abstracts: Weldon et al. 173 (1): 15
Low Microparticle Diet Shows Promise in Crohn’s Disease
This study took patients with Crohn’s disease off of all inorganic molecules, with titanium dioxide being one of the chemicals (titanium dioxide is a commonly used food additive). So, basically, these patients were put on a whole-food, low processed diet. This is ALWAYS a recommendation for just about any health condition; and in Crohn’s disease other nutrients like glutamine and probiotics would be added into the mix.
Eur J Gastroenterol Hepatol 2001;13:101-106 A diet low in microparticulate contaminants may promote remission in patients with Crohn’s disease. Dr. Jonathan J. Powell and colleagues, from St. Thomas’ Hospital in London, note that they have recently identified inorganic microparticles within intestinal phagocytes, and that microparticles may induce inflammation in susceptible individuals. To examine the effect of reducing microparticle intake, the investigators randomized 20 patients with active Crohn’s disease to receive a low microparticle diet or a control diet for 4 months. In keeping with current thoughts about Crohn’s disease, fibrous fruit and vegetables were avoided in both groups. The intervention diet excluded foods that could contain microparticles of titanium dioxide and aluminosilicates. Fresh fruit and vegetables were peeled and washed to minimize soil contamination. Filtered water was used for all activities where ingestion might occur and toothpastes and pharmaceuticals that might contain titanium dioxide were avoided. Except for a diminished calcium requirement, the diet met UK standards for energy and nutrient intake. Over the 4-month period, the Crohn’s disease activity index decreased significantly in the trial group and seven patients achieved disease remission, Dr. Powell and colleagues report. This beneficial result did not occur in the control group and none of these patients achieved disease remission. The trial group also showed a trend toward a greater reduction in corticosteroid intake compared with the control group. “This is the first study of the tolerability and efficacy of a diet that is low in inorganic microparticles,” the investigators point out. The beneficial results achieved with this diet may “explain the efficacy of elemental/polymeric diets, although, compared to [the low microparticle] diet, they are more expensive, less palatable and patients would probably be less compliant,” the researchers emphasize.
T lymphopaenia in relation to BMI and TNF-a in human obesity
This is a nice article suggesting one way to lower TNF-alpha levels via weight loss. With the new class of drugs used for rheumatoid arthritis and Crohn’s disease that block TNF-alpha action this is a refreshing article showing natural, healthy ways to have the same effect.
Synergy : Clinical Endocrinology 54 (3), 347-354
Anti-TNF, IL-10, antibiotics in indometacin-induced bowel inflammation
This is an interesting article that implicates both TNF-alpha and anaerobic bacteria in the development of Crohn’s disease. So we are using fancy new drugs to block TNF-alpha (we all know my opinion on THIS one…); where is the other half of the therapy designed to address to harmful bacteria? A global approach to Crohn’s includes probiotics, avoidance of refined sugars and managing insulin levels and obesity (both stimulate TNF-alpha production).
Synergy : Alimentary Pharmacology & Therapeutics 15 (11), 1827-1836
M. avium subsp. paratuberculosis as one cause of Crohn’s disease
Crohn’s disease has the potential to be a devastating autoimmune disorder where the body attacks its own GI tract. Like many other chronic diseases, much emphasis has been placed on finding an ineffective etiology to the onset of this disease. This overall supports this ineffective cause, and ties it very nicely to multiple causes of the disease. The interesting thing about functional medicine is that many of the therapies are similar–achieving optimal health is achieving optimal health, regardless of the cause that got the patient sick in the first place.
Aging, Immunity, and Cancer
This is a review of the current literature supporting the idea that our immune system is constantly fighting off cancer, and it is the slowing of the immune system response with age that increases our risk for cancer. This really does shed new light on many new therapies coming out that focus on suppressing the immune response, such as the new TNFalpha inhibitors for rheumatoid arthritis and Crohn’s disease. We don’t fully understand how our bodies work, and blocking a step in this process may have unforeseen consequences.
Cancer Control; JMCC 7(6):513-522, 2000 Background: The prime function of the immune system is to protect the entire organism from a variety of insults and illnesses, including the development of cancer. The question of how age-related declines in immune function contribute to an increasing incidence of malignancies continues to be a focus of discussion and speculation. Conclusions: Senescent decline in immune surveillance leads to the accumulation of cellular and DNA mutations that could be a significant factor in the development of malignancy and programmed cell death or apoptosis observed in the elderly.
T cell reactivity to microbial antigens, collagen in RA after new meds
Etanercept is the new drug being used to treat rheumatoid arthritis and Crohn’s disease. I have always been concerned at the effects of blocking the action of TNF-gamma in the body. A more rational approach would be to use natural methods to block the production of TNF-gamma (anti-inflammatory diets, herbs, maintaining good insulin sensitivity, lowering the level of adipose tissue…). New research is suggesting that this new drug upregulates the immune system further, with the potential for even more autoimmunity–the reason the drug is used in the first place!!
Ann Rheum Dis — Abstracts: Berg et al. 60 (2): 133