Reproductive hormonal dynamics in the perimenopause
This is an older article but one I had to throw in just to blow apart standard thinking. So many people (and physicians included0 believe that perimenopausal symptoms are a result of lack of estrogens. The treatment? More estrogen, of course (in the form of equine estrogens foreign to the human body). Unfortunately, the reality is that perimenopause is associated with elevated estrogens. The symptoms of perimenopause are from rapid changes in estrogen levels, not elevated estrogen. Blunt the peaks with progesterone cream (downregulates estrogen receptors and makes cells less sensitive to estrogen) and fill in the troughs with phytoestrogens and most of the symptoms and signs of perimenopause disappear…
JCEM — Abstracts: Santoro et al. 81 (4): 1495