L-5-methyltetrahydrofolate vs folic acid on plasma homocysteine – (03-04-03)



L-5-methyltetrahydrofolate vs folic acid on plasma homocysteine.

Oral folic acid needs to be converted by the enzyme MHTFR to 5-MTHF before it can be used by the body in the methylation pathways. As has been previously discussed in Updates, the enzyme MHTFR is a common site of genetic differences, with certain genotypes producing a very sluggish enzyme that does not readily activate the oral folic acid. The idea has been that, by giving 5-MHTF directly, you can bypass genetic defects. This study does not support this theory, but it was also done on normal patients without consideration of their genetic makeup.

AJCN — Abstracts: Venn et al. 77 (3): 658

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James Bogash

For more than a decade, Dr. Bogash has stayed current with the medical literature as it relates to physiology, disease prevention and disease management. He uses his knowledge to educate patients, the community and cyberspace on the best way to avoid and / or manage chronic diseases using lifestyle and targeted supplementation.







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