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WHAT ARE THE ADDITIONAL BENEFITS OF LOWERING CHOLESTEROL – (02-21-05)
Tocotrienols: Constitutional Effects in Aging and Disease
Tocotrienols are Vit E’s more powerful cousin and usually kept in the closet. However, they are present in some of the higher quality vitamins as well as a wide variety of foods like rice bran and certain oils like palm.
We have known that they have some powerful antioxidant properties for awhile, but this review suggest additional benefits of lowering cholesterol and, as a wonderful bonus considering the increase in neurodegenerative disorders, reducing glutamate-induce neurotoxicity.
This would suggest that those people with seizures or at increased risk of Alzheimer’s or Parkinson’s should put this one on the protective list.
ASSOCIATION BETWEEN DIETARY ARGININE AND C-REACTIVE PROTEIN – (03-28-05)
Association between dietary arginine and C-reactive protein
We really can’t let information like this get out. That would totally ruin the drug company’s hopes for the next blockbuster drug when they finally figure out how to lower CRP pharmaceutically. Of course, the fact that managing insulin resistance, exercise and fish oils bring down CRP levels has not stopped them.
But, mark my words–the second it is confirmed that a drug lowers CRP levels (there are currently several trials of the potential for statins to lower CRP), there will be advertisements all over telling patients to have their CRP levels checked… We saw the same push with irritable bowel syndrome once the new anti-motility drugs were released.
FISH OILS AND FLAVONOIDS REDUCE ARRHYTHMIAS – (03-28-05)
QTc Prolongation by Grapefruit Juice and its Potential Pharmacological Basis
After a class I taught recently, I had a patient come up and ask me about coumidin’s interaction with other natural compounds (specifically, I believe, fish oils). She was on coumidin for atrial arrhythmia which, quite frankly, is not a bad idea if nothing else is attempted.
However, with rising evidence of fish oils and now flavonoids being able to reduce arrhythmias, the permanent use of blood thinning agents may need to be re-evaluated. Especially in the light that patients on blood thinners have to avoid most green leafy veggies which have unquestionable major benefits on long term health.
MULTIVITAMIN – AN ESSENTIAL COMPONENT OF GOOD HEALTH – (04-04-05)
Roles for Cell Death in Zinc Deficiency
Every normal cell has the ability to undergo programmed cell death called apoptosis. Too much apoptosis plays a role in neuron death in Alzheimer’s, Parkinson’s, ALS and seizures.
This review reminds us how incredibly important zinc is in keeping this in check. Zinc deficiency in mice leads to a 300% increase in cell death, including a nasty form called autophagy, where the cell feeds off its own organelles to survive. This really, once again, supports the use of a good quality multivitamin as an absolute essential component of good health.
VITAMIN D DEFICIENCY IS DUE TO UNREASONABLE FEAR OF THE SUN – (05-01-05)
Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced by long-wave ultraviolet radiation in melanoma cells
I still contend that the increase in melanoma rates in our kids are not from increased sun exposure, but rather from reduced intake of compounds that may protect us from sun damage and cancer formation. It is estimated that as high as 75% of the population is vit D deficient, and the unreasonable fear of the sun is contributing to this extreme deficiency numbers.
HOW MUCH VITAMIN D IS CONSIDERED TO BE ADEQUATE? – (05-23-05)
Vitamin D and calcium deficits predispose for multiple chronic diseases
I continue to rant on about how much research there is supporting Vit D and how much we’ve become deathly afraid of the sun. Estimates range that as high as a whopping 75% of the population are Vit D deficient. Given that it has been shown to protect against colon, prostate and breast cancer, atherosclerosis, certain forms of depression (specifically seasonal affective disorder), increase insulin sensitivity, strengthen bones, and probably many other things I can recall now, this is a major concern. Even more of a concern is how much Vit D we consider “adequate.” Normal sunlight exposure produces about 10,000 IU per day.
There is a wonderful review (Read More full text also available) that debunks the “upper safety threshold” of 2,000 IU–suggesting that daily intakes up around 4,000 IU are probably what should be recommended. Contrast that with the current recommendations of a paltry 400 IU–almost 10 times below!!
VITAMIN C CAN PROTECT FROM REPURFUSION INJURY – (05-23-05)
Hypoxia–reoxygenation-induced mitochondrial damage and apoptosis in human endothelial cells are inhibited by vitamin C
Many people are unaware of this, but with a stroke or heart attack, the area that is initially deprived of oxygen is actually SMALLER than the area that ultimately dies off. This is because when a cell is starved for oxygen and that oxygen gets rapidly brought back, the cell is not prepared and mitochondrial damage occurs that can result in further cell death. So, patients in the middle of a heart attack or stroke are frequently given drugs like TPA in the hospital to dissolve out the clot that is blocking blood flow.
We know have much evidence in support of compounds like magnesium, CoQ10 and now vitamin C that can protect from repurfusion injury. While I do not know personally, I do not believe that giving high doses of these compounds by IV prior to repurfusion is being done on a regular basis. I’m just not sure if I would be in a position to convey my desire for these compounds prior to repurfusion should I ever end up in this situation. I would be a nice thing to have tattooed to my forearm, though…
HOW TO REDUCE NOISE TRAUMA? – (12-03-07)
Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma
Sometimes the breadth of health related conditions that can be affected by nutrition really astounds me.
In this study, it reviews that noise related hearing loss actually occurs as a result of free radical production in the cochlea. The combination of these antioxidants, but not each individually, resulted in strong protection to hearing loss. So, next time you go to your Iron Maiden concert or Nascar.
EARLY SUN EXPOSURE REDUCES BREAST CANCER RISK – (11-05-07)
Vitamin D and Reduced Risk of Breast Cancer: A Population-Based Case-Control Study
I just spent this past weekend volunteering at the Breast Cancer 3-day in the medical tent providing injury care to the walkers. Invariably, in conversation with patients, the question of why they were walking came up. I will always remember the response of an 18 yr old girl who’s mom died of breast cancer 5 yrs ago. I asked her what SHE was doing to prevent breast cancer for herself. She replied with some degree of frustration that “they” won’t do anything because she was too young. Of course she was referring to mammography. But how twisted has our society become that we, at it’s most important moment, confuse prevention with early detection?
This study is a perfect example of how much can be done to intervene in the process. But given our aversion to preventing cancer, and that this study found that early exposure (10-19 years of age) to the sun cut risk by 35%, how many generations will it be before we pass knowledge of prevention from the adults that “get it” to the youth that “need it??”
HOW VITAMIN D SUPPLEMENTATION HELPS DURING PREGNANCY? – (11-05-07)
Vit D Intake During Pregnancy and Risk of Recurrent Wheeze in Children at 3 Years of Age
The rates of vit D deficiency in pregnant women and their newborn babies is unconscionably high. While immediate concerns like rickets jump to mind, of greater concern is how important Vit D is for health immune system balance.
The findings of this study further cement this importance and, extrapolated out, would have impacts on asthma, allergy and autoimmune risk years later. Supplementation of pregnant women with Vit D is very cheap, safe and easy. Individual dosages can be given in a one time dose a month or so before delivery. We need to move on this as a medical culture or this fear mongering of sun exposure is going to further drain our healthcare future.
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