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CHRONIC FATIGUE SYNDROME – (03-06-05)
Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise
For many years, conditions like chronic fatigue and irritable bowel were considered psychogenic because no physiological alterations could be found. Well, it’s not that they weren’t there–we just didn’t know where to look.
This study just confirms what many of us in manual medicine have known for some time–these patients are very prone to “overtreatment.” Do too much, exercise too much or go too deep and the patient will be very sore the next day.
Following the results of this article, it is logical to assume that these patients would respond very favorable to interventions designed to support the mitochodria and reduce oxidative stress.
WHAT ARE GOOD BIOMARKERS OF OXIDATIVE STRESS? – (03-28-05)
Biomarkers of Oxidative Stress Study II: Are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning?
Don’t you just love this? An instant contribution to our dilemma!! While the jury is still out, we are starting to gather evidence as to what are good markers of oxidative stress.
This study did support the use of malondialdehyde (MDA) as a marker–which is wonderful because there is already a very easy urine at-home test available that is also very inexpensive. Stay tuned as more research comes out.
WHAT IS A GOOD SOLID TEST TO CHECK OXIDATIVE STRESS – (04-25-05)
Urinary 20-hydroxyeicosatetraenoic acid excretion is associated with oxidative stress in hypertensive subjects
Not to confuse anyone with long words (just how much would that be worth in Scrabble?) but it is surprising to me just how many ways we are finding to evaluate oxidative stress. Truly this is a wonderful movement, because we are still lacking a good, overall, solid test to check for oxidative stress.
What I can see happening is a panel of several oxidative stress markers that will give a good idea of what state a patient is in. Given that I think oxidative stress/mitochondrial dysfunction is the root of all evil, any markers we can identify to evaluate this is a good thing.
NAC HELPS TO PREDICT THE KIDNEYS IN THE EVENT OF A BAD REACTION – (05-08-05)
N-Acetylcysteine for the Prevention of Contrast-induced Nephropathy
Remember that NAC exerts one of its main actions by increasing the amount of available glutathione, and that glutathione is one of the body’s more potent antioxidant molecules as well as a major participant in detoxification.
This was a review and meta-analysis of several studies, with the consensus being that NAC helps to predict the kidneys in the event of a bad reaction to dyes used in diagnostic imaging. The problem is that it needs to be administered 12 hours prior to the testing. It would be nice to see if oral dosages would be as effective as IV.
In the meantime, probably a good idea to pop some NAC if you’re having any imaging done that requires contrast medium.
PHYSICIANS ARE HUMAN AND CAN MAKE MISTAKES! – (05-08-05)
Iatrogenic events resulting in intensive care admission: Frequency, cause, and disclosure to patients and institutions
Let’s face it…physicians are human. Mistakes will always happen. However, when mistakes are made, we need to face up to it. A simple “I’m sorry” can go a long way with patients.
In this study, 1.2% of patients in the ICU were there because of iatrogenic events (doctor-caused). 33% of these were because of their meds. In only 5% of the cases, where the patients were in the ICU because of their prior medical treatment, were the patients or patients caregiver informed of this.
The sad case is that, if most clinicians were current on the medical literature, many of these conditions probably would’ve been managed differently with a much better outcome (lifestyle changes = less drugs = less likelihood for dangerous side effects).
LONG TERM EFFECTS OF STRESS REDUCTION ON MORTALITY – (05-16-05)
Long-Term Effects of Stress Reduction on Mortality in Persons ¡Ý55 Years of Age With Systemic Hypertension
So stress reduction makes you healthier and lowers your risk of dying from many diseases. Big deal. But a 49% decrease in risk of cancer in participants performing meditation? Holy anti-carcinogens, Batman!! That is cutting your risk of cancer in half from meditation alone. There was also a 23% reduction in all cause mortality and 30% reduction in cardiovascular mortality. These numbers are staggering.
EVALUATING OXIDATIVE STRESS IN THE BRAIN – (05-16-05)
Increased oxidative damage in subjects with mild cognitive impairment
I still contend that the only thing keeping us from more effectively managing neurodegenerative disorders is our ability to effectively and conveniently monitor oxidative stress in the brain.
This is another article that is beginning to answer the question of which marker is effective in evaluating oxidative stress in the brain.
MATERNAL NUTRITION CAN DECIDE THE UNBORN CHILD’S HEALTH – (12-03-07)
Maternal Nutrition, Low Nephron Number, and Hypertension in Later Life: Pathways of Nutritional Programming
This is yet another pathway by which forcing women into pregnancy artificially, whose bodies are not ready for pregnancy because of physiological imbalances, is upsetting the balance of our health. The evidence is piling up that the decisions made in pregnancy can haunt that unborn child’s health for decades into the future.
In this article, the idea is put forth that, when mom is not eating properly, the fetus will develop a lower number of filtration units (nephrons) in the developing kidneys. Later in life, as that child becomes overweight (because they will be at increased in risk for obesity because of the unhealthy mom), this will place excess burden on the kidneys, resulting in kidney failure. Add to this mix a society that doesn’t realize the dangers of NSAIDs on the kidneys and you’ve got a nasty increase in dialysis centers.
FACTORS CONTRIBUTING TO DYSPEPSIA – VIT C, STRESS – (10-29-07)
Initial Poor Quality of Life and New Onset Dyspepsia
Given that digestive problems are strongly related to lifestyle, the results of this study are not surprising. We know that probiotics help with H. pylori infection and it is likely that destruction of normal flora sets up the H. pylori infection in the first place. Lower levels of Vit C contribute. Stress greatly contributes. All these factors that can contribute to dyspepsia would also contribute to other health related problems.
That doesn’t even take into account what happens when we suppress gastric acid production with drugs. The bottom line is that dyspepsia needs to be addressed w/ lifestyle changes for the best results.
A PARADIGM OF GENOME STABILITY – (09-17-07)
Circadian tempo: A paradigm for genome stability?
Wow!! What a concept. Our body’s ability to repair damaged DNA does not occur evenly throughout the day, but seems to be at its peak at the time of day when the DNA is most likely to be exposed to higher levels of DNA damage.
So, if this holds true, then what about patients that have problems sleeping, work night shifts or are stressed? Might this be another mechanism by which these conditions lead to cancer?
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