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Bldg 7, Ste 135
Mesa, AZ 85210
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Gut health 101

Current Gallbladder Pain – Blame Your Younger Years

Sure-you remember fondly back on your youth, high school and college days.  I remember doing things as a child that, if I saw my son doing them, I would think he’s out of his mind and I was doing a poor job as a father.  Then there’s the near-permanent frontal lobe damage so many seem to accomplish in college (which, by the way, is not true–the brain remains plastic long into our adult years).  But did you ever think about about what damage is being done to our gallbladders?

Given the state of medicine today, one would think that the gallbladder is near-vestigial and can be taken out on a whim with nary a price to pay. 

First, we need to understand some of the basic functions of the gallbladder.  The absolute most important job of the gallbladder is to store the bile that is constantly produced in the liver and release bile in response to the hormone CCK in response to a fatty meal.  The bile released then helps to emulsify and absorb the fat and fat soluble nutrients of our meal.

So what happens after a cholecystectomy (gall bladder removal)?  There are several negative consequences.

  1. Most common is diarrhea.  This is because there is now unabsorbed fat in the intestinal tract (no bile to help with the absorption) which contributes to the osmotic diarrhea commonly seen.  Luckily, supplements containing bile acids can very successfully relieve the diarrhea.
  2. Fat soluble nutrient absorption problems.  This includes the fat soluble vitamins A, D, E and K, but also fat soluble phytonutrients like lycopene (the red pigment in tomatoes that are known to protect the prostate and heart) and a long list of others.  Supplementation with certain vitamins is essential.
  3. Increased risk of colorectal cancer.  The reasoning is not quite worked out, but it likely has to do with the constant slow release of bile acids from the liver that are no longer stored.  Because they aren’t stored and released to bind up with fats as needed, they are free to float down into the intestinal tract and create problems among cells that are not designed to handle the acids. Eating certain foods regularly may help bind up the bile acids and lower the risk of harm.

These little tidbits are rarely shared with patients prior to their surgical removals (which, by the way, is actually required–it’s called informed consent and is grounds for malpractice).  All too often, even severe gallbladder attacks are NOT grounds for gallbladder removal, despite popular opinion.  Recent studies suggest less than a third of patients with severe symptoms will continue to have problems.  This means that more mild symptoms should not even initiate the conversation.

Of course, the real answer is not damaging our gallbladder in the first place.  And this, while trying to avoid sounding like a broken record, is almost always a result of being prediabetic.  I’ve always told patients that gallbladder problems can occur decades before someone actually becomes diabetic.  So, of course, fixing the gallbladder has everything to do with pulling back from a pro-diabetic lifestyle.

This particular article gives us some insight into just how early this process starts.  Researchers found that obese preadolescents actually began to have problems with gallbladder motility long before they became an adult. 

I do not need to stress to anyone just the life altering importance of raising our children with good lifestyle habits and maintaining an ideal body composition.  If your child is NOT in this category, you need to understand fully that the damage to their delicate bodies has already begun.

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CHRONIC FATIGUE SYNDROME – (03-06-05)

Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise

For many years, conditions like chronic fatigue and irritable bowel were considered psychogenic because no physiological alterations could be found.  Well, it’s not that they weren’t there–we just didn’t know where to look.

This study just confirms what many of us in manual medicine have known for some time–these patients are very prone to “overtreatment.”  Do too much, exercise too much or go too deep and the patient will be very sore the next day.

Following the results of this article, it is logical to assume that these patients would respond very favorable to interventions designed to support the mitochodria and reduce oxidative stress.

Read entire article here

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TWO STRONGEST MARKERS TO PREDICT RELAPSE – (03-06-05)

Calprotectin is a stronger predictive marker of relapse in ulcerative colitis than in Crohn’s disease

It is strange that two of strongest markers to predict relapse are tests most GI docs have probably never heard of.  Altered GI permeability (“leaky gut”) as evidenced by a lactulose/mannitol challenge is another strong predictor of relapse.

The nice thing is that these markers can be easily checked and modified with natural approaches such as omega-3 fatty acids, non-processed diets and probiotic supplementation.

Read entire article here

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DO YOU KNOW THAT THE BACTERIAL FLORA HAS AN IMPACT ON OUR HEALTH? – (03-06-05)

Bacterial counts of intestinal Lactobacillus species in infants with colic

There is no longer a question that the bacterial flora in our bodies (pharynx, stomach, SI, LI, vaginal vault..) have an impact on our health.  While many clinicians that wouldn’t recognize a medical journal if it hit them in the face remains oblivious to this fact, the research, as always, moves on.  We are now focusing on the types and levels of bacteria that positively and negatively impact our health.  Considering the number of bacteria in our gut, this job is not an easy one.

The research comes in in bits and pieces, but I’m sure that we will soon have a much clearer picture of the impacts different species have on our health.  Maybe then our focus will shift away from antibiotic resistance to the much larger problem of destroying normal, protective flora.

Read entire article here

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EXERCISE, DIET AND NUTRITION ARE LESS DANGEROUS THAN DRUGS – (03-28-05)

Effect of two alpha-glucosidase inhibitors on postprandial hyperglycemia correlates w/ abdominal symptoms

That’s just great.  The person who is most likely to respond to this class of drugs is the one who has the most stomach upset from the drug.  At some point don’t we have to decide that exercise, diet and targeted nutritional supplementation are just a little easier and less fatal?

Read entire article here

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EFFECT OF SOY CONSUMPTION – (04-04-05)

The Effect of Soy Consumption on 2:16-Hydroxyestrone Ratio in Postmenopausal Women Depends on Equol Production Status but is not influenced by Probiotic Consumption

Here’s some background…the body metabolizes estrogens down several pathways.  The “2″ pathway is considered protective for certain types of cancer while the “16″ pathway is damaging.  It is known that equols, compounds produced by bacterial conversion of soy isoflavones in the gut, shift the metabolization of estrogen to the 2 pathway (so does indole-3-carbonol from cruciferous veggies).

So, the idea in this study was to give probiotics with soy to see how much of an effect on equol levels was seen.  There seems to be a subset of women that respond positively to this approach, but the researchers were not able to identify specifics.  I do have a question for the more research-minded readers out there…

This study used a 2 week washout period.  How can you get a washout period using probiotics?  All things being healthy–the probiotics should maintain in the GI tract.  I wonder how much this influenced the results?

Read entire article here

 

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Heartburn or Prediabetes, Which Leads to Esophageal Cancer?

There are times when it seems like every other patient coming into my office is on some type of acid blocker drug to treat their ulcer or heartburn.  Most have the mistaken belief that they make too much stomach acid.  Consider this: stress lowers stomach acid production and stomach acid production drops as we get older.  With these two factors alone, do you think there is anyone who makes too MUCH stomach acid these days?

The easy answer is no.  However, if someone has a bleeding ulcer, blocking the acid production will likely save his or her life.  Every other case is likely to do much more harm than good.  The list of problems associated with acid blocking drugs is quite long.  This should come as no surprise given that stomach acid is absolutely essential for a large number of critical processes in the human body (digestion, activation of other enzymes, sterilization of bacteria, activation of the pancreas, absorption of certain nutrients, activation of anti-cancer compounds, etc…).

The list includes:

The recommendation for acid blocker drugs in many times goes beyond symptom relief and more into the mistaken belief that acid blocking drugs will prevent the progression to Barrett’s esophagus and then to esophageal cancer.  As you can see from the study above, the opposite is true.  These drugs may actually increase the risk for the condition many doctors are trying to prevent.

This particular article adds weight to this, suggesting that prediabetes is as great of a risk factor, if not greater, for the development of Barrett’s esophagus than is reflux.  In some cases quadrupling the risk.  This means that the approach to managing any type of gastric issue, whether reflux, ulcer or gastritis needs to involve the whole spectrum of lifestyle changes to head the patient away from diabetes.  Shocking to hear me say this, but true.

The other thing to consider is that, most often, patients with heartburn actually make too LITTLE stomach acid.  Supporting digestion, using probiotics and improving the diet can go av very long way towards getting rid of reflux for good.

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USE OF PROBIOTICS CAN CHANGE THE COMPOSITION OF THE BACTERIAL FLORA – (05-01-05)

Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces

Before the title causes your eyes to glaze over, let me put this in a better light.  This study confirms that bacteria present along the respiratory tract can amplify inflammation occurring in the airways.

This study specifically looked at Haemophilus influenzae and Streptococcus pneumoniae. So why is this interesting?  Studies have shown that the use of probiotics such as lactobacillis can change the composition of the flora of the nasopharynx to less Strep and Staph and more Lactobaccillis.  That can go in reverse–kill off normal flora with antibiotics, stick with processed foods present in todays’ foods (fermented foods such as yogurt and miso and tempeh contain probiotics, while Staph and Strep are pretty much found everywhere) so the good bacteria doesn’t get replaced, and Viola–instant source of increased airway inflammation.

Read entire article here

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WHAT TYPE OF PROBIOTICS ARE GOOD FOR HEALTH? – (05-01-05)

Dietary Fructooligosaccharides increase Intestinal Permeability in Rats

Okay, so this is a rat study and the amount of FOS given to the rats was excedingly high (4500 GRAMS for an average sized male human–I thought this might be an error, but no corrections have been noted), but this study still illustrates that probiotics and prebiotics given willy-nilly is not always a good thing.

We still have much to learn on this important topic, and much research is focused on identifying what types of probiotics are good for what application (IBS, lower inflammation, immune stimulatory…).  It may be years yet before we fully understand all the nuances of pre/probiotic use.

Read entire article here

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CHECK FOR BACTERIAL FLORA IF YOU HAVE SEVERE DIARRHEA – (04-25-05)

Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

I saw a patient yesterday that I hadn’t seen in about three years.  She had pretty severe diarrhea predominant IBS and we ran Great Smokies CDSA.  For those of you not familiar with this test, one of the things it checks for is bacterial flora.  The sad part for this patient is that she showed this test to numerous providers and specialist she had seen since, and none said it had any value.  I apologized to the patient for the lack of current knowledge for her providers.

This article is a perfect example of how far behind clinical practice is.  Most clinicians are maybe just catching onto the idea of what probiotics, as a general term, are.  But the research moves on and we are now identifying the different physiological effects different strains have on the GI tract.  Once we are able to pin this info down, the therapeutic potential will definitely rise.

Read entire article here

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