Archive for ovarian cancer
Milk and lactose intakes and ovarian cancer risk
Women who drank more than 4 servings of dairy per day had a twofold increased risk for one type of ovarian cancer. For those of us against dairy this just further supports our position. As an aside, do you ever wonder why some articles never make it to the mainstream press?
Milk and lactose intakes and ovarian cancer risk in the Swedish Mammography Cohort — Larsson et al. 80 (5): 1353 — American..
Milk, milk products and lactose intake and ovarian cancer risk
I don’t make this stuff up–I just find it. While this review does not show a strong association, it does show that increasing milk intake does increase your risk of ovarian cancer. As a society, we really need to re-evaluate our fascination w/ dairy. There are few dietary recommendations made that do not include dairy as a part of the equation. It’s association w/ health is incredibly pervasive, despite only a weak benefit at best. At worst, increasing intake of dairy products contribute to chronic diseases.
Dairy Products and Ovarian Cancer
While the association between ovarian cancer and 3 servings of dairy per day was not that strong, the fact that any risk was there is of concern given the blind faith we give in dairy products. I have patients that guiltily admit that they don’t drink milk and so are worried about their bone health. I have patients in community health presentations that are astounded that I would even suggest that dairy is not good for us. I will continue to give the dairy industry credit for one of the most phenomenol marketing campaigns in history: getting the American public to religiously believe that dairy is absolutely essential to good health despite very minimal evidence to support this.
Coffee, Tea, Colas, and Risk of Epithelial Ovarian Cancer
Tea, in particular green tea, is well known for is health promoting benefits. This particular study found a 54% reduction in the risk of ovarian cancer with >1 cup per day of green tea consumption. This is a very large reduction in risk for such a simple intervention that would also likely have risk reductions across other disease states.
We live in a society that steadfastly promotes the drinking of 8-10 glass of water per day with literally NO evidence to support this recommendation, and much evidence to support the potential harm in drinking water from plastic bottles contaminated with hundreds of environmental toxicants. I strongly urge patients to abandon the 8-10 glass theory and switch to drinking tea. Switching to 8-10 glasses of green tea has documented health effects across the board of chronic disease risk.
Ovarian Conservation at the Time of Hysterectomy and Long-Term Health
This is another one of those studies that smashes down decades-old dogma in health care (i.e. smoking is good for you, HRT prevents heart disease, total cholesterol is associated with heart disease, aspirin a day saves lives..). It has been somewhat standard to remove a woman’s ovaries at the time of hysterectomy because…well…just because.
Unfortunately, this study finds some serious flaws in this approach (in this study, over half the women had their ovaries removed). With the exception of cancers of breast and ovaries, all other indices of mortality went up (all cause, heart disease, other cancers). For women under 50 who had bilateral oopherectomies done and chose not to take HRT, an extra 1 in 9 women will die because of the removal of the ovaries. And to think that these doctors get paid extra to remove the ovaries should be abhorrent given these statistics.
Vitamins Use in a Male Physicians and Subsequent CVD.
This article found no protective effect for multivitamins or vitamins C or E on cardiovascular disease. Before you run to the cabinet and throw away your Centrum multis (on second thought…if you are taking Centrum….) consider a few things. These articles rarely look into the type of multivitamin that the participant is taking. Multi quality varies incredibly, and my biased opinion would be that the researchers would have a hard time identifying characteristics of a high quality multivitamin. Just because a multi has 100% of the RDA does not mean it will be absorbed. Many nurses in the past have referred to Centrums as “bedpan bullets.” And ask any radiologist if they have identified intact vitamins on Xray. (see Dr. Bogash – vitamins & Herbs http://www.lifecarechiropractic.com/vitaminsherbs.html for additional information on this topic) My guess would be that a good, high quality multivitamin WILL lower risk of many diseases, CVD included.
Vitamin Supplement Use in a Low-Risk Population of US Male Physicians and Subsequent Cardiovascular Mortality - Click here for more information.
The Hospital Water Supply as a Source of Nosocomial Infections.
I’ve always said that hospitals are a dangerous place to be!! Chalk up yet another reason. I have to relay a recent experience. I had one of my oldest patient fall and break her hip. Hip replacement surgery followed and she was placed into a rehab/nursing facility. I gave her daughter Vitamin C and zinc (both are excellent for wound healing — vitamin C can be a limiting factor for formation of connective tissue; without it healing can slow down). The nursing staff went apoplexic and took them away and said they needed to ask the doctor. Of course, the doctor denied them and wrote a prescription for multivitamin (which are notoriously low quality). The ignorance of this situation is astounding and all too familiar.
The Hospital Water Supply as a Source of Nosocomial Infections: A Plea for Action - Click here for more information.
Outbreak of Multiresistant A. baumannii and Pseudomonas aeruginosa.
Combine this article with the previous one and we can begin to see why some patients never leave the hospital. Patients enter there immunocomprimised in the first place, are given nutritionally devoid (and in some cases harmful) food and on top of all of this are exposed to some strong bugs. Remember that a healthy immune system, NOT antibiotics, does not care about “multiresistant” bugs. The human immune system, when optimally functioning, can take care of these invaders quite readily. The bottom line? We need to support the immune systems of patients at risk; not destroy it with poor food and nutritional deficiencies. Click here for more information.
Sunlight and breast, ovarian, colon, prostate, non-melanoma skin cancer.
We have such fears these days of sunlight exposure and have forgotten that sunlight is actually healthy for us (in moderation, of course). This article shows a protective effect of sunight exposure on many types of cancer. Recently, much press was given here in AZ on the increasing rates of melanoma in children. So of course we heard from “experts” on how properly apply sunscreen and stay out of the sun. A few things to consider here. Do you think that kids today have less actual sun exposure now than 20 years ago? The push for sunscreen, kids staying indoors to play video games… I would bet total sunlight exposure is down and yet melanoma is up. How?? Gosh forbid we should consider a overall health and nutritional impact on melanoma. I would like to see further studies comparing overall sun exposure as well as looking into dietary considerations now versus 20 years ago. Occup Environ Med — Abstracts: Freedman et al. 59 (4): 257 - Click here for more information.
Predisposition to Atherosclerosis by Infections.
This article adds further weight to the contribution of infections to cardiovascular disease. There is a growing list of factors that contribute to risk, and many, if not most, can be managed with lifestyle changes…CRP, cholesterol, homocysteine, HDL cholesterol and now infections. Maintaining a lifestyle that supports healthy immune function (avoiding refined carbs, lots of fruits and veggies..) can help lower risk of infections and possibly lower CVD risk. Circulation — Abstracts: Prasad et al. 106 (2): 184 - Click here for more information.
A Controlled Trial of Arthroscopic Surgery for Osteoarthritis of the Knee.
This study really explodes another very common procedure in mainstream medicine. Arthroscopy of the knee is very common, and yet the research to support its validity has never been done. Well, this article does some of this research and shows no benefit over placebo (the issue of a placebo surgery is an another topic entirely…). Articles like this always bring to mind the critics of chiropractic care who say what we do is not founded on research. Well, those doctors in incredibly fragile glass houses on foundations of cards should not shoot anti-aircraft missles….NEJM — Abstracts: Moseley et al. 347 (2): 81 - Click here for more information.
Can flossing teeth foil heart disease?
This short review supports further the notion that healthy gums means healthy heart. This may refer back to a few articles ago–the gums can be a route of infection into the human body; thus increasing the exposure to bacteria. Flossing is of course a very good idea, but I would also add to that the use of xylitol gum. Xylitol is a naturally occurring sugar that seems to have an effect on the normal flora of the oral cavity–changing it to a less invasive phenotype. The Journal : Back Issues - Click here for more information.
Hip abductor activation with clinical unilateral hip osteoarthritis.
While this article seems blatantly obvious to those of us in manual medicine that use alot of soft tissue techniques, we appearantly needed a study so others could share in the obvious. Consider a tent with one of the tethering lines pulling way too hard–of course there would be long term effects on the health and durability of the main pole. Stretching, mobilization of the hip joint, orthotics, trigger point therapy and techniques aimed at eliminating scar tissue (i.e. NMR, ART) are important components of a therapeutic approach to hip pain. Ann Rheum Dis — Abstracts: Sims et al. 61 (8): 687 - Click here for more information.
Very Early Exposure to Erythromycin and Infantile Pyloric Stenosis.
So many times we consider antibiotic use with blinders on. We just look at long term side effects as antibiotic resistance without looking at how we destroy normal flora and here, how this drug alters stucture to create a condition that requires surgical intervention. All clinicians need to come to terms with the long term detrimental effects of antibiotic use and use only when absolutely necessary.
Very Early Exposure to Erythromycin and Infantile Hypertrophic Pyloric Stenosis. Click here for more information.
Exposure to pets and atopy-related diseases in the first 4 years of life
More and more studies are showing a protective effects of pets on allergies in children. The sterile environment that we are raising our kids, with no pets, antibacterial-everything, over vaccination and antibiotic use with every snifle is altering the developing child’s immune balance in an unhealthy way. Synergy : Allergy 56 (4), 307-312 http://onlinelibrary.wiley.com/doi/10.1034/j.1398-9995.2001.00881.x/full
Ipriflavone in the Treatment of Postmenopausal Osteoporosis
I’ve quite frequently expressed by views towards using whole foods whenver possible. Nature put certain compounds into our food that can interact positively with each other. By trying to isolate and mass produce the believed active ingredient we may be missing out on the interactions of these substances working together to achieve the best clinical response with the least amount of side effects. I firmly believe that soy is the same way–we are abusing the key components of soy. And remember that the approach to today’s chronic diseases requires attacking the problem from all angles–not just one aspect. Ipriflavone in the Treatment of Postmenopausal Osteoporosis: A Randomized Controlled Trial http://jama.ama-assn.org/content/285/11/1482.abstract
ERT and Ovarian Cancer Mortality in Women
Not only are we consistently beating down to perceived benefits to HRT, but the list of adverse effects continues to grow. First of all, menopause IS NOT A DISEASE!! You will not find it in any of the pathology books. Second, if you want to lower your risk of heart disease and osteoporosois there are many other ways to do this without increasing your risk for cancer. Estrogen Replacement Therapy and Ovarian Cancer Mortality in a Large Prospective Study of US Women http://jama.ama-assn.org/content/285/11/1460.abstract?maxtoshow=%3Feaf
Insulin Resistance Syndrome
This is a wonderful review article covering one of the major health damaging effects of our time. A definate read for anyone not entirely clear on insulin resistance and its effect on our health. Insulin Resistance Syndrome – March 15, 2001 – American Family Physician http://www.aafp.org/afp/20010315/1159.html
Low-Energy Trauma Capable of Producing Significant Injuries
This article showed that up to 1/3 of patients in this study that sufferred relatively minor trauma sustained serious, life-threatening injuries. Now, while chiropractors do not typically deals with these types of patients, we do see patients everyday who were involved in relatively minor accidents and yet have significant levels of discomfort and injuries. This article just supports what chiros have been saying for decades.
J Am Coll Surg 2001;192:147-152 Low-energy trauma can produce significant injuries, and trauma physicians should be careful about dismissing patients with seemingly insignificant mechanisms of injury, according to a report published in the February issue of the Journal of the American College of Surgeons. Dr. George C. Velmahos, from the Los Angeles County and University of Southern California Medical Center, in Los Angeles, and colleagues assessed the significant injuries of 110 patients who sustained ground-level falls, 95 patients who sustained low-level falls, and 96 patients who were found down with no evidence of significant trauma. More than a third of patients had significant injuries, 20 patients required admission to an intensive care unit, 14 required an operation, and 4 died, the authors state. The most common types of injuries were intracranial and skeletal. Nearly every patient received a CT scan, but only one quarter had abnormal CT findings.
Breastfeeding Linked to Increased Risk of Atopy and Asthma
This is one of those articles that the media will love to use to try to scare the heck out of mothers. However, much like the vitamin C research that shows an increase in DNA damage (further delving revealed that vitamin C also protects against more severe and damaging types of DNA damage…) one study does not set the standard in stone. While I can’t think of a rationale as to why the use of a therapy deemed highly beneficial would show a negative relationship. It would be interesting to evaluate the diets of the mothers for potential allergens that the infant would be exposed to…
57th Annual Meeting of the American Academy of Allergy, Asthma and Immunology Dr. Malcolm R. Sears from McMaster University in Hamilton, Canada and colleagues assessed the impact of breastfeeding on the development of atopy and asthma by comparing data on 504 subjects who were breastfed for at least 4 weeks with data on 533 subjects who were not. Skin testing at age 13 revealed that breastfed subjects were significantly more likely than their counterparts to have a positive reaction to cat, dust mite, or any tested allergen. In fact, this effect was evident on repeat testing at age 21 years. In addition, breastfed subjects were more than twice as likely as their cohorts to have been diagnosed with asthma by 9 years of age. The effects of breastfeeding seen at 13 years of age were independent of maternal or paternal history of atopic disease, first born or non-first born status, and gender, the researchers note. However, at age 21 years the effects were most evident and significant in male subjects. “The majority of review papers and advice given says breastfeeding is good because it reduces your risk of developing allergy and asthma,” Dr. Sears told Reuters Health. “However, the evidence is mixed and our study, which analyzes a New Zealand cohort, found just the opposite effect,” he said. “Our study differs from previous studies in that the prior studies were short term and often looked at early childhood wheezing which often is not allergic-based,” Dr. Sears pointed out. “We know that breastfeeding reduces the likelihood of infection; therefore it may have improved the outcome for infection-based wheezing,” he explained.
Increased Physical Activity Tied to Asthma in Children
Man, it sure is “debunk preventative medicine” day! Once again we have an article that suggests that an activity previously thought of as a good thing may have some negative aspects. Something to remember before you run out to stop your child from playing hard…high levels of physical activity will increase metabolism and increase the demand for antioxidants. With today’s child eating a diet very low in certain antioxidants, an increase in activity is a prescription for chronic disease… 57th Annual Meeting of the American Academy of Allergy, Asthma and Immunology Overall, 9.1% of white children and 12.5% of black children had asthma diagnoses. The researchers found that yearly physical activity was significantly higher in asthmatic than non-asthmatic children. Multivariate analysis adjusting for race, gender, birth weight, body mass index, percent body fat, and physical activity revealed that only physical activity was significantly related to the prevalence of asthma. However, separate analysis for each race failed to identify a significant association in black children. “There has been concern brewing about the increasing prevalence of asthma in children in this country,” Dr. Ownby noted in an interview with Reuters Health. One theory, he said, “had been that because children weren’t playing as hard as they used to, they weren’t expanding their lungs as much and thus they were at a higher risk of developing asthma.” However, “we found just the opposite was true,” he said. Dr. Ownby’s team used metabolic equivalents (mets) to quantify the various levels of physical activity. One met was equal to sitting quietly. Standardizing physical activity “allowed us to compare judo class with soccer practice or ballet,” Dr. Ownby explained. “I think this study will stir up some controversy because several people have been preaching [the conventional wisdom] based on pretty shaky data or data extrapolated from other countries,” Dr. Ownby noted. “As far as we know, our study is one of the most detailed studies investigating this issue in the United States.” Dr. Ownby believes that a “diagnostic bias” may explain the current findings. “The children who are more physically active may be more likely to have the symptoms of asthma and therefore be more likely to get diagnosed,” he said.
More Evidence Supports Infectious Cause of Childhood Leukemia
Here we see another example of the theory that many of today’s chronic diseases (in which I classify cancer…) have multiple etiologies. Infectious origins have been suggested for many diseases, including heart disease, rheumatoid arthritis and multiple sclerosis. This study looks at the exposure of children in Scotland to servicemen during WWII and the subsequent increase in leukemia in this population. Leading a healthier lifestyle will lower your risk of many types of diseases as well as boost your immune system at the same time. Could it be that this boost in immune function is actually the route by which healthier lifestyles lower the risk of certain diseases?
Lancet 2001;357:858 UK investigators have documented a significant increase in childhood leukemia deaths in an isolated rural population exposed to servicemen stationed nearby during World War II. The findings support the theory, they say, that an infectious agent is responsible for childhood leukemia. Drs. Leo J. Kinlen and A. Balkwill, both of the University of Oxford, examined death registries for two complete cohorts from Orkney and Shetland, in Scotland. The first cohort consisted of all 8574 children up to age 14 living on those two islands in 1941, plus 3690 children born there between 1941 and 1945. The postwar cohort consisted of 6478 children born in Orkney and Shetland from 1946 to 1955. During the war, up to 60,000 servicemen were stationed on the two islands, with an additional 40,000 stationed aboard a ship near Orkney. Local residents numbered fewer than 45,000. The researchers documented a 3.6-fold increase in leukemia deaths in the wartime group, whereas in the postwar cohort, followed until 1970, there was no increased risk of leukemia compared with age-specific leukemia mortality rates for Scotland. Drs. Kinlen and Balkwill explain that there was a great deal of contact between local people and servicemen during wartime “through regular social events, servicemen buying local produce, and local people working for army camps.” In addition, they note, “outside populations consisted almost wholly of adults, which points to their relevance in the transmission of the infection underlying childhood leukemia.” “Childhood leukemia must be a rare response to the underlying infection,” they suggest, adding that the agent or agents involved have yet to be determined.
Extended-Release Niacin Safe for Diabetics W/ Hypercholesterolemia
There has been some concern in the past with regards to the safety of using niacin with diabetics. This study evaulated a 1 and 1.5 gram dose of extended release niacin in diabetics. These dosages of typically much lower than has been used in other studies (typically 2-3 grams are used); however, these patients were already on additional cholesterol-lowering medications and this may be the reason for the lower dose used. Overall, the results were favorable, with the 1.5 gram dose having some effect on glycemic control. Both dosages were very effective in increasing HDL levels.
50th Annual Scientific Session of the American College of Cardiology Diabetics with poorly controlled cholesterol levels despite statin therapy can be safely given extended-release niacin. The combination significantly improves the lipid profile without adversely affecting glycemic control, Texas researchers reported . In the past, niacin has been shown to worsen glycemic control in diabetics, Dr. Gloria L. Vega of the University of Texas Southwestern Medical Center in Dallas said, even though niacin corrects the lipid abnormalities typically seen in diabetes. In her presentation to conference attendees, Dr. Vega described how she and her colleagues tested extended-release niacin (Niaspan, Kos Pharmaceuticals, Miami) in 148 diabetics with abnormal lipid profiles, many on statin therapy, in a 16-week trial. The researchers compared the effects of 1 gm and 1.5 gm extended-release niacin with placebo. Dr. Vega reported that 1 gm extended-release niacin increased high-density lipoprotein cholesterol levels 19% and 1.5 gm increased them 24%, while placebo had no significant effect. Levels of low-density lipoprotein cholesterol did not change significantly with either placebo or 1 gm niacin, while they dropped 8% with the 1.5 gm dose. Triglyceride levels dropped 24% and 29% for patients on 1 gm and 1.5 gm extended-release niacin, respectively. Fasting blood glucose and hemoglobin A1c levels did not change during the study in the placebo and 1 gm arms of the study, but patients on 1.5 gm niacin had a worsening of glycemic control. “We are very excited about this study,” Dr. Vega told Reuters Health. “Extended-release niacin can be incorporated into the treatment regimen of diabetics….It can be used with statin therapy or triglyceride-lowering drugs….There was no increase in liver enzymes and no increased weakness” during the study period, she added. “Certainly you are not going to take a patient with poor glycemic control and try this,” Dr. Vega said. “But most physicians are not aware that niacin can effectively increase HDL….Niacin has a bad reputation in terms of glycemic control, but you can control that with drugs rather than discontinue the niacin,” she asserted.
US moves to tighten law on health supplements
This is very dangerous grounds to tread on. On one hand, we do have many outrageous claims made for various supplements that the consumer has a hard time judging as false. On the other hand, increased regulation would ironically place supplements out of the realm of chiropractors and naturapaths–the physicians most qualified to give advice. I personally would rather have the government err on the side of no regulation–I feel that the consumers at potential harm due to the lack of regulation pales in comparison to the consumers benefitting from the use of supplements. bmj.com Josefson 323 (7314): 654f http://bmj.com/cgi/content/full/323/7314/654/f
SSRI antidepressants and upper GI bleeding in elderly patients
This is a new finding to me, and should be a consideration for anyone considering the pharmaceutical route for depression. I see many patients come through my office that have taken that route, and it is a long one involving drug changes, weight gain and no real light at the end of the tunnel. A natural approach using exercise, dietary changes, probiotics (acts on trypthophan to increase circulating levels of serotonin…) and maybe St John’s Wort or SAMe, if the patient can be motivated, are much more effective and definately safer. bmj.com Abstracts: van Walraven et al. 323 (7314): 655 http://bmj.com/cgi/content/abstract/323/7314/655
Antidepressants as risk factor for ischaemic heart disease
I don’t make the articles…I just point them out. Someone at the BMJ must have it out for antidepressants this month!! bmj.com Abstracts: Hippisley-Cox et al. 323 (7314): 666http://bmj.com/cgi/content/abstract/323/7314/666
Dairy products, calcium, and prostate cancer risk
“Milk it does a body good??” Brilliant marketing work of the years, I must admit. Sort of like “Pork–the other white meat.” (Comes from a pig!! When was the last time you called bacon “white meat?”). Milk is a common allergen, loaded with chemicals and hormones, may contribute to osteoporosis according to some studies, and now we see it may increase cancer risk. Can anyone see any good reason to continue to consume dairy products? AJCN — Abstracts: Chan et al. 74 (4): 549 http://www.ajcn.org/cgi/content/abstract/74/4/549
Red meat and ovarian cancer risk
Two compounds in cooked meat, heterocyclic amines (HCA) and polyaromatic hydrocarbons have been shown consistantly to be carcinogenic. Most studies have looked at colon cancer risk, but this study shows an association with ovarian cancer as well. This is not a great surprise, since these compounds can be absorbed into the circulation and wreak havoc elsewhere. Article Abstract http://www3.interscience.wiley.com/cgi-bin/abstract/85005744/START
Probiotics as an Option for Treating, Preventing Urogenital Infections?
It’s nice to see this question come up on the Medscape website. I’ve had many patients achieve near-miraculous results with yeast infections and other vaginal irritations using probiotics douches. The concept is so simple as to be almost laughable–growth of lactic acid bacteria such as lactobacillus create an envirnoment that is not friendly to many other bugs and yeast. And lactobacillus is normal flora–does not cause any problems.
Medscape Women’s Health 6(5), 2001 Considering the enormity of the problem in terms of women infected per year, urogenital infections receive far too little attention from scientists, government funding agencies, and the pharmaceutical industry. A recent resurgence in interest among clinicians is a result of consumer demands for better therapies, problems resulting from drug resistance, and the prospect of new diagnostics and treatments on the horizon. It is now recognized that the intestinal and urogenital microflora are critical for the health and well-being of humans. The concept of replenishing these flora with probiotic organisms seems to be an option that has a growing scientific basis. Although few strains have been selected and targeted for urogenital applications, and none are currently available on the market, evidence shows that probiotic therapy has the potential to make an impact on women’s health.