Folate and vitamin B-12 and risk of fatal cardiovascular disease
Here is a study that finds and recommends no benefit from supplementation on CVD. At first I was a little surprised, until I looked further into the study. The study did not look at supplementation and yet, in the summary, recommended that routine recommendation not be used until more studies are done. This study checked blood levels of folate and B12. However, we know that one of the main factors about whether supplementation will help is status of the MHTFR enzyme. In about 25% of the population, this enzyme has a difficult time converting folate into its active form 5-methyltetrahydofolate. If you want to find out if this is related, you need to check 5-MHTF levels in the blood and risk of CVD.
bmj.com Hung et al. 326 (7381): 131