COX-2 Expressed at High Levels in Pancreatic Tumors
This study demonstrated high levels of COX-2 in several types of pancreatic tumors, and the addition of COX-2 inhibitors slowed the growth of the tumors. Now, before we jump up and down at this discovery and throw lost of research money into the study of COX-2 inhibitors and pancreatic cancer, we must remember Dr. Gonzalez’s work using high levels of pancreatic enzymes, detoxification, coffee enemas and other healthy lifestyle changes. Normal survival for pancreatic cancer rarely exceeds 19 months. Period. In a small study, Dr. Gonzalez achieved 45% survival rate at 2 yrs, with four of eleven patients still surviving.
Entrez-PubMed
Cancer 2001;91:333-338 Over half of pancreatic tumors express cyclooxygenase-2 (COX-2), Japanese researchers report. In addition, COX-2 inhibitors can inhibit the growth of pancreatic cancer cells in vitro. The researchers also investigated the effect of the COX-2 inhibitors aspirin and etodolac on the growth of four pancreatic cancer cell lines, of which two expressed COX-2 weakly and two expressed the protein strongly. Both drugs inhibited the growth of the cells. “Although the reason remains unclear, there was a negative correlation between the intensity of COX-2 expression and the 50% inhibitory concentration of aspirin but not of etodolac,” the authors write. They conclude that COX inhibitors are “possible preventive agents against pancreatic neoplasms.”